高中四年级的Peter Parker是一名孤儿学生，与他的婶婶May 和叔叔Ben 住在一起。在学校的实地考察中，他和他的朋友Harry Osborn 以及他的爱恋之人Mary Jane Watson 一起参观了一个遗传学实验室。然后，Peter 被一只基因工程的“超级蜘蛛”咬伤，“超级蜘蛛”是实验室的实验之一。回到家后，他视物模糊，失去了知觉。
导演：山姆·雷米 Sam Raimi
主演：托比·马奎尔 Tobey Maguire
威廉·达福 Willem Dafoe
克尔斯滕·邓斯特 Kirsten Dunst
詹姆斯·弗兰科 James Franco
克里夫·罗伯逊 Cliff Robertson
罗斯玛丽·哈里斯 Rosemary Harris 地区：美国，语言：英语，字幕：英文
高中四年级的Peter Parker是一名孤儿学生，与他的婶婶May 和叔叔Ben 住在一起。在学校的实地考察中，他和他的朋友Harry Osborn 以及他的爱恋之人Mary Jane Watson 一起参观了一个遗传学实验室。然后，Peter 被一只基因工程的“超级蜘蛛”咬伤，“超级蜘蛛”是实验室的实验之一。回到家后，他视物模糊，失去了知觉。与此同时，Harry 的父亲、科学家Norman Osborn，一位亿万富翁，也是奥斯科普的所有者，正试图赢得一份重要的军事合同。他用一种不稳定的性能增强剂对自己进行实验。在使用了这种化学物质后，他疯了，杀死了他的助手Stromm 博士……
High-school senior Peter Parker, a school outcast, lives with his aunt May and his uncle Ben. On a school field trip, he visits a genetics laboratory with his friend Harry Osborn and his love interest Mary Jane Watson. Peter is then bitten by a genetically engineered “super spider”, one of the laboratory’s experiments. After arriving home, his eyesight dims and he falls unconscious. Meanwhile, Harry’s father, scientist Norman Osborn, a billionaire and the owner of Oscorp, is trying to win an important military contract. He experiments on himself with an unstable performance-enhancing chemical. After applying the chemical, he goes insane and kills his assistant, Dr. Stromm.
When he regains consciousness, Peter finds that he is no longer near-sighted, and his body has transformed into a more muscular physique. At school, he finds that his hands can produce webs, and his quickened reflexes allow him to avoid injury during a confrontation with Flash Thompson. Peter discovers he has developed superhuman speed, strength, the ability to stick to surfaces, and a heightened ability to sense danger.
Ignoring Ben’s advice that “With great power comes great responsibility”, Peter plans to buy a car to impress Mary Jane. He participates in an underground fighting tournament and wins his match, but the promoter cheats him and refuses to pay him the reward money.
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